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There is consistent evidence that benzodiazepines may enhance appetite for food by relatively direct means. However, the evidence that they overcome food neophobia, and thereby increase food intake as a secondary effect, fails to be conclusive. Recent food selection studies nevertheless point to two dissociable actions of the drugs. At lower dose levels, benzodiazepines may act relatively selectively to mimic the effects of increased hunger. At higher dose levels, however, they display effects which are consistent with an action to reduce food neophobia. These behavioural studies indicate that appetitive effects of benzodiazepines are distinguishable from their anxiolytic effects. Clinically, this may point to an effective use of benzodiazepines in the treatment of feeding disorders.

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The present study investigated the effect of alprazolam on the pattern of food intake in seven male participants living in a residential laboratory for 17 days. A wide selection of meals, snacks and beverages was freely available. Capsule administration occurred at 1300 and 1730 hours. Food intake on days when alprazolam (0.75 mg) was administered (days 2, 11) was compared to days when no capsule (days 1, 9) or placebo (days 3, 10) was administered. Alprazolam increased total caloric intake by approximately 975 kcal from a baseline of 2800 kcal. Alprazolam increased the number of eating occasions occurring in the evening (1700-2330 hour), without altering the size of eating occasions (kcal), or the proportion of total calories derived from carbohydrate, fat and protein. These data demonstrate alprazolam's robust effects on food intake in humans.

 

Read more: http://www.drugs-forum.com/forum/showthread.php?t=31024#ixzz2nChskwnK

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