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[Mbleble1990]

Piribedil

Piribedil.svg

Piribedil ball-and-stick model.png

Clinical data

AHFS/Drugs.com International Drug Names

Routes of

administration Oral

ATC code

N04BC08 (WHO)

Legal status

Legal status

In general: ℞ (Prescription only)

Pharmacokinetic data

Bioavailability 10% (peak at 1 hour)

Protein binding 70–80%

Metabolism extensive hepatic

Biological half-life 1.7–6.9 hours

Excretion Renal (68%) and biliary (25%)

Identifiers

IUPAC name[show]

CAS Number

3605-01-4 Yes

PubChem CID

4850

IUPHAR/BPS

49

ChemSpider

4684

UNII

DO22K1PRDJ

KEGG

D07305 Yes

ChEMBL

CHEMBL1371770

ECHA InfoCard 100.020.695

Chemical and physical data

Formula C16H18N4O2

Molar mass 298.340 g/mol

3D model (JSmol)

Interactive image

SMILES[show]

InChI[show]

Yes (what is this?) (verify)

Piribedil (trade names Pronoran, Trivastal Retard, Trastal, Trivastan, Clarium and others) is an antiparkinsonian agent and piperazine derivative which acts as a D2 and D3 receptor agonist. It also has α2-adrenergic antagonist properties.[1][2]

 

Contents

1 Indications

1.1 Other uses

2 Dosage

2.1 Parkinson's disease

2.2 Other indications

3 Adverse effects

4 Interactions

5 Overdose

6 Receptor affinities

7 See also

8 References

Indications

Treatment of Parkinson's disease (PD), either as monotherapy (without levodopa)) or in combination with L-DOPA therapy, in the early stages of the disease as well as in the advanced ones

Treatment of pathological cognitive deficits in the elderly (impaired attention, motivation, memory, etc.)

Treatment of dizziness in the elderly

Treatment of retinal ischemic manifestations

Adjunctive treatment of intermittent claudication due to peripheral vascular disease (PVD) of the lower limbs (stage 2)

Adjunctive treatment of anhedonia and treatment-resistant depression in unipolar and bipolar depressives (off label)

Treatment of gait disorders associated with Parkinson's disease (no related cause) and other forms of parkinsonism

Other uses

The drug has been shown to enhance working memory capacities in normal aging adults.[3]

 

In age-related memory impairment, it has a positive effect on psychophysiological state of elderly people, improving memory and attention and increasing the velocity of psychomotor reactions and lability of nervous processes.[4]

 

It enhances cognitive skill learning in healthy older adults.[5]

 

It showed a positive effect in restless legs syndrome.[6]

 

Dosage