Starting doses in the range of 10 to 25 mg daily (for ‘little-old-ladies’ around 5 mg) are appropriate and should be taken as a single dose at night (because of its longish half-life, and contrary to a number of extant recommendations, it is pointless to take it three times a day).
Experience and evidence suggest it is prudent and worthwhile to give smaller doses, 25-75 mg, plenty of time, 6 – 8 weeks, to show their potential benefits before escalating further.
https://www.psychotropical.com/clomipramine-potent-snri-anti-depressant/